Study on virus killing efficiency and related properties of a composite hand &amp; skin antiseptics containing chlorhexidine

Pingle Zhou

doi:10.11910/j.issn.2791-2043.2023.1.04

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Study on virus killing efficiency and related properties of a composite hand & skin antiseptics containing chlorhexidine

MONOGRAPHIC STUDY | Updated：2023-03-27

- Study on virus killing efficiency and related properties of a composite hand & skin antiseptics containing chlorhexidine
- Sterile Supply Vol. 2, Issue 1, (2023)
- Affiliations：
  
  1.Hangzhou Hygen Health Biotechnology Co., Ltd., 310018, Hangzhou, Zhejiang, China
- Author bio：
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- DOI：10.11910/j.issn.2791-2043.2023.1.04
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Zhou Pingle.Study on virus killing efficiency and related properties of a composite hand & skin antiseptics containing chlorhexidine[J].Sterile Supply,2023,02(01):28-33.
DOI：

Zhou Pingle.Study on virus killing efficiency and related properties of a composite hand & skin antiseptics containing chlorhexidine[J].Sterile Supply,2023,02(01):28-33. DOI： 10.11910/j.issn.2791-2043.2023.1.04.

摘要

Abstract

Objective,2,To verify the virus killing efficiency, stability and clinical safety of a composite hand & skin antiseptics containing chlorhexidine.,Methods,2,The suspension inactivation test, physical & chemical analysis, accelerated aging study and animal toxicity test were executed to evaluate the virus killing efficiency, stability and clinical safety of the composite hand & skin antiseptics.,Results,2,The composite hand & skin antiseptics containing 0.45 % gluconic acid gluconate, 75 % ethanol and synergists was used for 1 min, the average inactivation of poliovirus type I (PV-I) and EV71 enterovirus in suspension were both >4.00. The sealed package was stored at 37 °C for 3 months, and its active ingredient decline rate was <10%. The composite hand & skin antiseptics is actually non-toxic; it has no micronucleus effect on mouse bone marrow polychromatic red blood cells; it has no irritation to white rabbit in multiple intact skin test.,Conclusion,2,The composite hand & skin antiseptics has a good killing performance on viruses with good stability. It is safe to use for skin and hand disinfection.

关键词

Keywords

Composite hand antisepticsChlorhexidineEthanolvirusInactivation efficiencyStability Clinical safety

references

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Study on virus killing efficiency and related properties of a composite hand & skin antiseptics containing chlorhexidine

DOI：10.11910/j.issn.2791-2043.2023.1.04

摘要

Abstract

关键词

Keywords

references