Cleaning, disinfection and sterilization equipment play an important role in the effective control of hospital infections. With the development of technology, more cleaning, disinfection and sterilization equipment are continuously used in clinical practice, and it is increasingly important to manage the quality control of related equipment properly. To achieve homogeneous management of cleaning, disinfection and sterilization equipment, the authors of this paper organized relevant personnel to compile a book entitled ,Quality Control Guide for Cleaning, Disinfection and Sterilization Equipment ,(hereinafter referred to as "Guide"), which is used to guide medical institutions at all levels to reasonably carry out. The author has organized a book entitled ,Quality Control Guide for Cleaning, Disinfection and Sterilization Equipment, (hereinafter referred to as "the Guide"), which can be used to guide medical institutions at all levels to carry out quality control of relevant equipment in a rational manner. This article provides a brief introduction to the types of equipment covered by the Guide, as well as relevant quality control items, methods and examples, to facilitate the use of the Guide by relevant professionals to perform quality control work and improve the safety and standardization of the use of cleaning, disinfection and sterilization equipment. The main target audience of this Guide includes medical engineers and technicians from various medical institutions, sterilization supply center managers, manufacturers' engineers and technicians and other professionals engaged in related work.