Objective,2,Based on RFID technology and computer programming, this study attempts to build an information management system for final sterilized textile packaging materials in the Central Sterile Supply Department (CSSD), which can control the process comprehensively and achieve the goal of quality traceability and information management.,Methods,2,The information management system for finally sterilized textile packaging materials was built and used to accomplish the desired functions through the process of information collection, mobile uploading and centralized management in the cloud based on the windows operating system, and system functions are expected to be achieved gradually.,Results,2,This information management system shows stability and operability by test run, which achieves the expected effect, making the synchronization of different networks under the non-physical link of internal and external network data possible.,Conclusion,2,The results provide robust implications that the application of finally sterilized textile packaging materials using RFID technology can realize intelligent counting in CSSD, making it possible to trace the quality and information management throughout the cleaning and disinfection process, thus ensuring the quality of the sterile packaging; besides, it enhances cost analysis and control ability of CSSD and improves management efficiency of finally sterilized textile packaging materials in clinical departments and operating rooms. It is of great significance to control infection, safeguard the safety of patients, and guarantee the overall quality of hospital services.