Hangzhou Hygen Health Biotechnology Co., Ltd., 310018, Hangzhou, Zhejiang, China
纸质出版:2023-03-15
Scan QR Code
Pingle Zhou. Study on virus killing efficiency and related properties of a composite hand & skin antiseptics containing chlorhexidine[J]. 消毒供应, 2023,2(1):28-33.
Zhou Pingle.Study on virus killing efficiency and related properties of a composite hand & skin antiseptics containing chlorhexidine[J].Sterile Supply,2023,02(01):28-33.
Pingle Zhou. Study on virus killing efficiency and related properties of a composite hand & skin antiseptics containing chlorhexidine[J]. 消毒供应, 2023,2(1):28-33. DOI: 10.11910/j.issn.2791-2043.2023.1.04.
Zhou Pingle.Study on virus killing efficiency and related properties of a composite hand & skin antiseptics containing chlorhexidine[J].Sterile Supply,2023,02(01):28-33. DOI: 10.11910/j.issn.2791-2043.2023.1.04.
Objective
2
To verify the virus killing efficiency
stability and clinical safety of a composite hand & skin antiseptics containing chlorhexidine.
Methods
2
The suspension inactivation test
physical & chemical analysis
accelerated aging study and animal toxicity test were executed to evaluate the virus killing efficiency
stability and clinical safety of the composite hand & skin antiseptics.
Results
2
The composite hand & skin antiseptics containing 0.45 % gluconic acid gluconate
75 % ethanol and synergists was used for 1 min
the average inactivation of poliovirus type I (PV-I) and EV71 enterovirus in suspension were both >4.00. The sealed package was stored at 37 °C for 3 months
and its active ingredient decline rate was <10%. The composite hand & skin antiseptics is actually non-toxic; it has no micronucleus effect on mouse bone marrow polychromatic red blood cells; it has no irritation to white rabbit in multiple intact skin test.
Conclusion
2
The composite hand & skin antiseptics has a good killing performance on viruses with good stability. It is safe to use for skin and hand disinfection.
ZHONG Y W , ZHANG L , LIU Z , et al . Study on the inactivation efficacy of ethanol and its effect on ultrastructure of poliovirus [J ] . Chin J Disinfect , 2019 , 36 ( 4 ): 246 - 249 .
CHEN L Y , ZHOU Y , LIN L W , et al . A comparative study on inactivated effect of two viruses to chlorine disinfectant [J ] . Prev Med Tribune , 2014 , 20 ( 12 ): 923 - 925 .
HUANG J G , WU L W , LUO Z H , et al . Detection and analysis of enterovirus EV71 and CoxA16 infection in hand, foot and mouth disease [J ] . Exp Lab Med , 2011 , 29 ( 3 ): 328 - 330 .
Georgios Ionidiset al . Development and virucidal activity of a novel alcohol-based hand antiseptics supplemented with urea and citric acid [J ] . BMC Infectious Diseases , 2016 ( 16 ): 77 .
P.Wutzler and A.Sauerbrei . Virucidal efficacy of a combination of 0.2% peracetic acid and 80%(v/v) ethanol(PAA-ethanol) as a potential hand antiseptics [J ] . Journal of Hospital Infection , 2000 ( 46 ): 304 - 308 .
LIU H D , LI W M , YUE R L , et al . Preparation of chlorohexidine acetates-silica composite antibacterial materials and their performances [J ] . China Powder Sci Technol , 2012 , 18 ( 6 ): 1 - 5 .
LU J L , ZHOU Y L , GUO Y C . Observation on the effect of chlorhexidine acetate bath in the treatment of early neonatal impetigo [J ] . J Nurs , 2014 , 21 ( 20 ): 58 - 59 .
XIN X M , ZHANG X R , WANG M H , et al . Discussion on the application of 0.5% chlorhexidine acetate alcohol solution in skin disinfection [J ] . J Zhangjiakou Med Collage , 1999 ( 1 ): 54 .
Edmiston CE , Jr Seabrook GR , et al . Comparative of a new and innovative 2% chlorhexidine gluconate-impregnated cloth with 4% chlorhexidine gluconate as topical antiseptic for preparation of the skin prior to surgery [J]. Am J Infect Control , 2007 , 35 ( 2 ): 89 - 96 .
RAO L , WEI Q H , REN Z , et al . Study on influence of acid synergist on viral inactivation effect by triclosan [J ] . Chin J Disinfect , 2014 , 31 ( 12 ): 1267 - 1269 .
CHEN L Y , ZHOU Y , LIN L W , et al . A comparative study on inactivated effect of two viruses to chlorine disinfectant [J ] . Prev Med Tribune , 2014 , 20 ( 12 ): 923 - 925 .
Thirty years on: HIV receptor gymnastics and the prevention of infection . Weiss RA . Wohl Virion Centre , Division of Infection & Immunity, University College London, Gower Street, London WC 1 E,
Eckert , DM , Kim , PS . Mechanisms of viral membrane fusion andits inhibition . Annu. Rev. Biochem . 2001 : 70 , 777 - 810 .
Bosch BJ , Martina BE , Van Der Zee R , et al . Severe acute respi-ratory syndrome coronavirus(SARS-CoV) infection inhibition usingspike protein heptad repeatderived peptides . Proc. Natl. Acad.Sci. U.S.A. , 2004 , 101 ( 22 ): 8455 - 60
Liu S , Xiao G , Chen Y , et al . Interaction between heptad repeat 1and 2 regions in spike protein of SARS-associated coronavirus: im-plications for virus fusogenic mechanism and identification of fusioninhibitors . Lancet 2004 , 363 : 938 - 947 .
Zhu J , Xiao G , Xu Y , Yuan F , et al . Following the rule: forma-tion of the 6-helix bundle of the fusion core from severe acute respi-ratory syndrome coronavirus spike protein and identification of po-tent peptide inhibitors . Biochem. Biophys. Res. Commun . 2004 , 319 : 283 - 288 .
Haywood A M. . 1994 . Virus receptors:binding,adhesion strengthening,and changes in viral strucrure . J.Virol. , 68 ( 1 ): 1 - 5
0
浏览量
104
Downloads
0
CSCD
关联资源
相关文章
相关作者
相关机构
苏公网安备 32010602011062号