Efficacy of Antimicrobial Materials on Environmental Surfaces: A 12-Week Prospective Controlled Trial

Caiyun Chen; Hao Liu; Yongxia Gao; Jing Zhou; Xiang Zhang; Bo Liu

doi:10.11910/j.issn.2791-2043.2025.4.07

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Efficacy of Antimicrobial Materials on Environmental Surfaces: A 12-Week Prospective Controlled Trial

MONOGRAPHIC STUDY | Updated：2026-05-22

- Efficacy of Antimicrobial Materials on Environmental Surfaces: A 12-Week Prospective Controlled Trial
- Sterile Supply Vol. 4, Issue 4, (2025)
- Affiliations：
  
  1.Department of Pharmacy, The First Affiliated Hospital of Nanjing Medical University
  2.Department of infection, Children's Hospital of Nanjing Medical University
  3.Department of Infectious Diseases, The First Affiliated Hospital of Nanjing Medical University
  4.Department of Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University
  5.Department of Infection Management, The First Affiliated Hospital of Nanjing Medical University
  6.Medical Administration Department, The First Affiliated Hospital of Nanjing Medical University
- Author bio：
  
  Email: cloudccy@163.com
  Email: liuhaoanhui@126.com
  Xiang Zhang at jsphzx@163.com
  Bo Liu at liusanbo@163.com
- Funds：
- DOI：10.11910/j.issn.2791-2043.2025.4.07
  CLC：
- Published：15 December 2025
- Accepted：
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Chen Caiyun,Liu Hao,Gao Yongxia,et al.Efficacy of Antimicrobial Materials on Environmental Surfaces: A 12-Week Prospective Controlled Trial[J].Sterile Supply,2025,04(04):289-295.
DOI：

Chen Caiyun,Liu Hao,Gao Yongxia,et al.Efficacy of Antimicrobial Materials on Environmental Surfaces: A 12-Week Prospective Controlled Trial[J].Sterile Supply,2025,04(04):289-295. DOI： 10.11910/j.issn.2791-2043.2025.4.07.

摘要

Abstract

Objective

This study aims to evaluate the sustained antimicrobial efficacy of antimicrobial materials on high-touch surfaces in an intensive care unit (ICU).

Methods

A prospective

controlled study was employed. An experimental group (surfaces coated with antimicrobial material) and a control group (surfaces receiving routine disinfection) were established in an ICU. Environmental surface sampling was performed at weeks 1

and 12

with microbial contamination measured as colony-forming units per square centimeter (CFU/cm

Results

Surface contamination was significantly lower in the experimental group at all assessment time points versus the control (Week 1: 0.42 vs. 2.31 CFU/cm

0.01)

with all experimental surfaces complying with the Class II specification (≤5 CFU/cm

) specified in the national standard

Hygienic standard for disinfection in hospitals

(GB 15982—2012). The experimental group showed a trend of initial slight increase and subsequent decrease in CFU counts

with overall contamination remaining low.

Conclusion

Antimicrobial materials can maintain continuous microbial control on environmental surfaces independently of chemical disinfectants

and offer a valuable supplementary measure for integration into healthcare infection prevention strategies.

关键词

Keywords

references

MATIAS K C , DA SILVA C L B , DA SILVA MEDEIROS H P , et al . Healthcare-associated infections controller: Concept development [J ] . Revista Brasileira de Enfermagem , 2025 , 78 : e20230443 .

BLOT S , RUPPÉ E , HARBARTH S , et al . Healthcare-associated infections in adult intensive care unit patients: Changes in epidemiology, diagnosis, prevention and contributions of new technologies [J ] . Intensive and Critical Care Nursing , 2022 , 70 : 103227 .

LIM O , CHUA W Y , WONG A , et al . The environmental impact and sustainability of infection control practices: A systematic scoping review [J ] . Antimicrobial Resistance & Infection Control , 2024 , 13 : 156 .

BELAY M M , AMBELU A , MEKONEN S , et al . Investigating microbial contamination of indoor air, environmental surfaces, and medical equipment in a southwestern Ethiopia hospital [J ] . Environmental Health Insights , 2024 , 18 : 11786302241266052 .

KEARNEY A , BOYLE M A , CURLEY G F , et al . Preventing infections caused by carbapenemase-producing bacteria in the intensive care unit - Think about the sink [J ] . Journal of Critical Care , 2021 , 66 : 52 - 59 .

PORTER L , SULTAN O , MITCHELL B G , et al . How long do nosocomial pathogens persist on inanimate surfaces? A scoping review [J ] . Journal of Hospital Infection , 2024 , 147 : 25 - 31 .

RUTALA W A , BOYCE J M , WEBER D J . Disinfection, sterilization and antisepsis: An overview [J ] . American Journal of Infection Control , 2023 , 51 ( 11 ): A3 - A12 .

WANG T C , FAN H Y , CHAI M Q , et al . Study on the disinfection efficacy of common commercial disinfectants in China against mastitis-causing pathogens and bedding materials in large-scale dairy farms [J ] . Veterinary Sciences , 2025 , 12 ( 11 ): 1072 .

LI C , GAO D D , LI C M , et al . Fighting against biofilm: The antifouling and antimicrobial material [J ] . Biointerphases , 2024 , 19 ( 4 ): 040802 .

WANG C Y , WEI X Y , ZHONG L , et al . Metal-based approaches for the fight against antimicrobial resistance: Mechanisms, opportunities, and challenges [J ] . Journal of the American Chemical Society , 2025 , 147 ( 15 ): 12361 - 12380 .

GUAN B Y , HUANG C H , KE Y Y , et al . Research progress on antibacterial coatings [J ] . Guangzhou Chemical Industry , 2025 , 53 ( 5 ): 1 - 5 .

BUTLER J P . Effect of copper-impregnated composite bed linens and patient gowns on healthcare-associated infection rates in six hospitals [J ] . Journal of Hospital Infection , 2018 , 100 ( 3 ): e130 - e134 .

MADDEN G R , HEON B E , SIFRI C D . Effect of copper-impregnated linens on multidrug-resistant organism acquisition and Clostridium difficile infection at a long-term acute-care hospital [J ] . Infection Control & Hospital Epidemiology , 2018 , 39 ( 11 ): 1384 - 1386 .

PAREEK V , GUPTA R , DEVINEAU S , et al . Does silver in different forms affect bacterial susceptibility and resistance? a mechanistic perspective [J ] . ACS Applied Bio Materials , 2022 , 5 ( 2 ): 801 - 817 .

LINKLATER D P , BAULIN V A , JUODKAZIS S , et al . Mechano-bactericidal actions of nanostructured surfaces [J ] . Nature Reviews Microbiology , 2021 , 19 ( 1 ): 8 - 22 .

DING Y , YANG G X , ZHENG S R , et al . Advanced photocatalytic disinfection mechanisms and their challenges [J ] . Journal of Environmental Management , 2024 , 366 : 121875 .

MONTERO D A , ARELLANO C , PARDO M , et al . Antimicrobial properties of a novel copper-based composite coating with potential for use in healthcare facilities [J ] . Antimicrobial Resistance & Infection Control , 2019 , 8 : 3 .

BIRKETT M , DOVER L , CHERIAN LUKOSE C , et al . Recent advances in metal-based antimicrobial coatings for high-touch surfaces [J ] . International Journal of Molecular Sciences , 2022 , 23 ( 3 ): 1162 .

D’ACCOLTI M , SOFFRITTI I , MAZZACANE S , et al . Fighting AMR in the healthcare environment: Microbiome-based sanitation approaches and monitoring tools [J ] . International Journal of Molecular Sciences , 2019 , 20 ( 7 ): 1535 .

RUTALA W A , WEBER D J . Best practices for disinfection of noncritical environmental surfaces and equipment in health care facilities: A bundle approach [J ] . American Journal of Infection Control , 2019 , 47 : A96 - A105 .

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