Effect of Different Moisturizing Agents on Cleaning Quality of Rigid Endoscopes: A Meta-Analysis

Xidan Zhang; Mingchun Yang; Weirui Zhang; Xiaorui Wei; Fayin Zhao

doi:10.11910/j.issn.2791-2043.2025.4.05

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Effect of Different Moisturizing Agents on Cleaning Quality of Rigid Endoscopes: A Meta-Analysis

REVIEW ARTICLES | Updated：2026-04-21

- Effect of Different Moisturizing Agents on Cleaning Quality of Rigid Endoscopes: A Meta-Analysis
- Sterile Supply Vol. 4, Issue 4, (2025)
- Affiliations：
  
  1.Yunnan University of Chinese Medicine
  2.Yan’an Hospital of Kunming City
- Author bio：
  
  Xidan Zhang
  Mingchun Yang at 735966014@qq.com
- Funds：
- DOI：10.11910/j.issn.2791-2043.2025.4.05
  CLC：
- Published：15 December 2025
- Accepted：
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Zhang Xidan,Yang Mingchun,Zhang Weirui,et al.Effect of Different Moisturizing Agents on Cleaning Quality of Rigid Endoscopes: A Meta-Analysis[J].Sterile Supply,2025,04(04):266-277.
DOI：

Zhang Xidan,Yang Mingchun,Zhang Weirui,et al.Effect of Different Moisturizing Agents on Cleaning Quality of Rigid Endoscopes: A Meta-Analysis[J].Sterile Supply,2025,04(04):266-277. DOI： 10.11910/j.issn.2791-2043.2025.4.05.

摘要

Abstract

Objective

This study aims to evaluate the effects on the cleaning quality of rigid endoscopes of four moisturizing agents

including multi-enzyme cleaner

self-made heparin

foam multi-enzyme moisturizer

and gel moisturizer.

Methods

A systematic search of Chinese and English databases covering CNKI

WanFang

VIP

CBM

PubMed

Web of Science

and Embase was conducted for randomized controlled trials (RCTs) evaluating moisturizing agents for cleaning rigid endoscopes from database inception to March 2025. Meta-analysis was performed using the software RevMan 5.3.

Results

A total of nine randomized controlled trials were included in the meta-analysis. Compared with multi-enzyme cleaner

self-made heparin significantly improved the cleaning pass rate of rigid endoscopes as assessed by visual inspection (

=1.01

95%

: 1.00~1.03;

=0.03) and residual protein test (

=1.01

95%

: 1.00~1.03;

=0.04). Foam multi-enzyme moisturizer demonstrated superior cleaning efficacy to multi-enzyme cleaner in ATP bioluminescence assay (

=1.23

95%

: 1.03~1.48;

=0.02) and occult blood test (

=1.10

95%

: 1.04~1.17;

=0.002). However

no statistically significant difference was observed between the two agents in visual inspection (

=1.04

95%

: 0.99~1.09;

=0.14) or residual protein test (

=1.08

95%

: 0.93~1.26;

=0.31). Gel moisturizer significantly outperformed multi-enzyme cleaner in both visual inspection (

=1.05

95%

: 1.03~1.08;

=0.001) and occult blood test (

=1.02

95%

: 1.00~1.05;

=0.02).

Conclusion

Self-made heparin and gel moisturizer demonstrated superior cleaning efficacy compared with the multi-enzyme cleaner for rigid endoscopes. Foam multi-enzyme moisturizer significantly outperformed multi-enzyme cleaner in ATP bioluminescence and occult blood tests but showed no significant advantage in visual inspection or residual protein testing. These findings support the selective application of alternative moisturizing agents based on cleaning assessment methods and clinical context.

关键词

Keywords

references

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