Bactericidal effects of four types of Didecyl dimethyl ammonium chloride and Benzalkonium Chloride

Defeng Li; Liang Tian; Xieshang Pan; Zhongyi Xie; Lanfen Wei

doi:10.11910/j.issn.2791-2043.2024.3.06

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Bactericidal effects of four types of Didecyl dimethyl ammonium chloride and Benzalkonium Chloride

MONOGRAPHIC STUDY | Updated：2026-02-06

- Bactericidal effects of four types of Didecyl dimethyl ammonium chloride and Benzalkonium Chloride
- Sterile Supply Vol. 3, Issue 3, (2024)
- Affiliations：
  
  1.BASTEUR (Shanghai) Disinfection Products Co., Ltd., Shanghai, 200120, China
  2.Shanghai Provincial Center for Disease Control and Prevention, Shanghai, 200120, China
  3.Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, 310051, China
- Author bio：
  
  Lanfen Wei at zjcdc0520@163.com
- Funds：
- DOI：10.11910/j.issn.2791-2043.2024.3.06
  CLC：
- Published：15 October 2024
- Accepted：
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Li Defeng,Tian Liang,Pan Xieshang,et al.Bactericidal effects of four types of Didecyl dimethyl ammonium chloride and Benzalkonium Chloride[J].Sterile Supply,2024,03(03):147-151.
DOI：

Li Defeng,Tian Liang,Pan Xieshang,et al.Bactericidal effects of four types of Didecyl dimethyl ammonium chloride and Benzalkonium Chloride[J].Sterile Supply,2024,03(03):147-151. DOI： 10.11910/j.issn.2791-2043.2024.3.06.

摘要

Abstract

Objective

The present study intends to observe the bactericidal effects of four types of Didecyl dimethyl ammonium chloride (DDAC) and Benzalkonium Chloride (BAC).

Methods

The bactericidal effects were evaluated using a quantitative suspension test and taking

Escherichia coli

(E. coli) (8099) and

Candida albicans

(C. albicans) (ATCC 10231) as the microbial indicators.

Results

With contact time of 5 minutes and 10 minutes and a killing rate criterion of ≥99.999% for effective bactericidal effects against E. coli

the minimum effective concentrations of the four types of DDAC and BAC were 3 500 mg/L

3 500 mg/L

250 mg/L

125 mg/L

and 350 mg/L

as well as 1 750 mg/L

1 750 mg/L

175 mg/L

125 mg/L

and 250 mg/L

respectively. With a contact time of 5 minutes and 10 minutes and a killing rate criterion of ≥99.99% for effective bactericidal effects against C. albicans

the minimum effective concentrations were >28 000 mg/L

>28 000 mg/L

500 mg/L

125 mg/L

and 350 mg/L

as well as >28 000 mg/L

>28 000 mg/L

250 mg/L

125 mg/L

and 350 mg/L

respectively.

Conclusion

Compared with BAC

a quaternary ammonium compound (QAC)

the bactericidal effects of different DDACs varied substantially

which should be highly emphasized in practice so that QAC disinfectants are applied effectively.

关键词

Keywords

references

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