

FOLLOWUS
1.PDI, Inc.
2.Boston University
3.PDI China
Ming Zhang at Michael.zhang@pdihc.com
Published:15 August 2025
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Hebden Joan N.,Jiang Yian,Zhang Ming.Current Science and New Technology for Universal Sporicidal Disinfectant[J].Sterile Supply,2025,04(02):84-91.
Hebden Joan N.,Jiang Yian,Zhang Ming.Current Science and New Technology for Universal Sporicidal Disinfectant[J].Sterile Supply,2025,04(02):84-91. DOI: 10.11910/j.issn.2791-2043.2025.2.04.
A key microbiological factor facilitating surface environment-mediated transmission of
Clostridioides difficile
(
C. difficile
)
norovirus (NoV) and
Candida auris (C. auris)
is their relative resistance to disinfectants used on environmental surfaces. Multiple outbreaks involving
C. difficile
NoV and
C. auris
in healthcare settings are linked to widespread environmental contamination. The notable resilience of
C. auris
underscores the need for broad-spectrum disinfectants with proven efficacy and a lower risk of material degradation. This review examines the current science understanding of
C. difficile
reservoirs in hospital environment
identifies deficiencies in cleaning practices for colonized and infected patient rooms
discusses the advantages and disadvantages of currently available sporicidal germicides
and explores the development of a non-bleach
hydrogen peroxide-based sporicidal agent.
WEBER D J , RUTALA W A , MILLER M B , et al . Role of hospital surfaces in the transmission of emerging health care-associated pathogens: Norovirus, Clostridium difficile, and Acinetobacter species [J ] . Am J Infect Contr , 2010 , 38 ( 5 ): S25 - S33 .
CHOWDHARY A , SHARMA C , MEIS J F . Candida auris: a rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally [J ] . PLoS Pathog , 2017 , 13 ( 5 ): e1006290 .
CARLING P C , PARRY M F , VON BEHEREN S M , et al . Identifying opportunities to enhance environmental cleaning in 23 acute care hospitals [J ] . Infect Control Hosp Epidemiol , 2008 , 29 ( 1 ): 1 - 7 .
BOYCE J M , HAVILL N L , LIPKA A , et al . Variations in hospital daily cleaning practices [J ] . Infect Control Hosp Epidemiol , 2010 , 31 ( 1 ): 99 - 101 .
RUPP M E , ADLER A , SCHELLEN M , et al . The time spent cleaning a hospital room does not correlate with the thoroughness of cleaning [J ] . Infect Control Hosp Epidemiol , 2013 , 34 ( 1 ): 100 - 102 .
HAN J H , SULLIVAN N , LEAS B F , et al . Cleaning hospital room surfaces to prevent health care–associated infections [J ] . Ann Intern Med , 2015 , 163 ( 8 ): 598 - 607 .
KANG J , SICKBERT-BENNETT E E , BROWN V M , et al . Relative frequency of health care-associated pathogens by infection site at a university hospital from 1980 to 2008 [J ] . Am J Infect Control , 2012 , 40 ( 5 ): 416 - 420 .
MAGILL S S , O’LEARY E , JANELLE S J , et al . Changes in prevalence of health care-associated infections in U.S. hospitals [J ] . N Engl J Med , 2018 , 379 ( 18 ): 1732 - 1744 .
LYTVYN L , MERTZ D , SADEGHIRAD B , et al . Prevention of clostridium difficile infection: a systematic survey of clinical practice guidelines [J ] . Infect Control Hosp Epidemiol , 2016 , 37 ( 8 ): 901 - 908 .
SRINIVASA V R , HARIRI R , FRANK L R , et al . Hospital-associated Clostridium difficile infection and reservoirs within the hospital environment [J ] . Am J Infect Contr , 2019 , 47 ( 7 ): 780 - 785 .
AHMED W I , MOHAMMED A N , SLEIM A A . Efficacy evaluation of hydrogen peroxide disinfectant based zinc oxide nanoparticles against diarrhea causing Escherichia coli in ruminant animals and broiler chickens [J ] . Sci Rep , 2024 , 14 ( 1 ): 9159 .
KHANDELWAL A , LAPOLLA B , BAIR T , et al . Enhanced disinfection with hybrid hydrogen peroxide fogging in a critical care setting [J ] . BMC Infect Dis , 2022 , 22 ( 1 ): 758 .
SHAMS A M , ROSE L J , EDWARDS J R , et al . Assessment of the overall and multidrug-resistant organism bioburden on environmental surfaces in healthcare facilities [J ] . Infect Control Hosp Epidemiol , 2016 , 37 ( 12 ): 1426 - 1432 .
BISWAS J S , PATEL A , OTTER J A , et al . Contamination of the hospital environment from potential clostridium difficile excretors without active infection [J ] . Infect Control Hosp Epidemiol , 2015 , 36 ( 8 ): 975 - 977 .
SHAUGHNESSY M K , MICIELLI R L , DEPESTEL D D , et al . Evaluation of hospital room assignment and acquisition of Clostridium difficile infection [J ] . Infect Control Hosp Epidemiol , 2011 , 32 ( 3 ): 201 - 206 .
MITCHELL B G , MCDONAGH J , DANCER S J , et al . Risk of organism acquisition from prior room occupants: an updated systematic review [J ] . Infect Dis Health , 2023 , 28 ( 4 ): 290 - 297 .
Crobach MJT , Vernon JJ , Loo VG , Kong LY , Péchiné S , Wilcox MH , Kuijper EJ . Understanding Clostridium difficile Colonization . Clin Microbiol Rev . 2018 Mar 14 ; 31 ( 2 ): e00021 - 17 .
LONGTIN Y , PAQUET-BOLDUC B , GILCA R , et al . Effect of detecting and isolating clostridium difficile carriers at hospital admission on the incidence of C difficile infections: a quasi-experimental controlled study [J ] . JAMA Intern Med , 2016 , 176 ( 6 ): 796 - 804 .
SITZLAR B , DESHPANDE A , FERTELLI D , et al . An environmental disinfection odyssey: evaluation of sequential interventions to improve disinfection of Clostridium difficile isolation rooms [J ] . Infect Control Hosp Epidemiol , 2013 , 34 ( 5 ): 459 - 465 .
AYUB A , CHEONG Y K , CASTRO J C , et al . Use of hydrogen peroxide vapour for microbiological disinfection in hospital environments: a review [J ] . Bioengineering (Basel) , 2024 , 11 ( 3 ): 205 .
COHEN S H , GERDING D N , JOHNSON S , et al . Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA) [J ] . Infect Control Hosp Epidemiol , 2010 , 31 ( 5 ): 431 - 455 .
Association for Professionals in Infection Control and Epidemiology . Guide to Preventing Clostridium difficile Infections . 2013 .
RUTALA W A , GERGEN M F , WEBER D J . Efficacy of different cleaning and disinfection methods against Clostridium difficile spores: importance of physical removal versus sporicidal inactivation [J ] . Infect Control Hosp Epidemiol , 2012 , 33 ( 12 ): 1255 - 1258 .
CADNUM J L , HURLESS K N , KUNDRAPU S , et al . Transfer of Clostridium difficile spores by nonsporicidal wipes and improperly used hypochlorite wipes: practice+product=perfection [J ] . Infect Control Hosp Epidemiol , 2013 , 34 ( 4 ): 441 - 442 .
RUTALA W A , WEBER D J . Selection of the ideal disinfectant [J ] . Infect Control Hosp Epidemiol , 2014 , 35 ( 7 ): 855 - 865 .
https://www.cloroxpro.com/wp-content/uploads/2018/09/Clorox-HC- Bleach-Grm-Wipes-tech-info-NI-38488.pdf Clorox Healthcare. https://www.cloroxpro.com/wp-content/uploads/2018/09/Clorox-HC-Bleach-Grm-Wipes-tech-info-NI-38488.pdfCloroxHealthcare. Accessed May 6 , 2019 .
MCDONNELL G , RUSSELL A D . Antiseptics and disinfectants: activity, action, and resistance [J ] . Clin Microbiol Rev , 1999 , 12 ( 1 ): 147 - 179 .
RUTALA W A , GERGEN M F , WEBER D J . Efficacy of improved hydrogen peroxide against important healthcare-associated pathogens [J ] . Infect Control Hosp Epidemiol , 2012 , 33 ( 11 ): 1159 - 1161 .
BOYCE J M , HAVILL N L . Evaluation of a new hydrogen peroxide wipe disinfectant [J ] . Infect Control Hosp Epidemiol , 2013 , 34 ( 5 ): 521 - 523 .
ULLAH I , NOMAN QAYYUM S , REHMAN E , et al . FDA’s new approach - adoption of vaporized hydrogen peroxide for medical equipment’s sterilization [J ] . Ann Med Surg (Lond) , 2024 , 86 ( 8 ): 4308 - 4310 .
BAILEY C , MAKISON-BOOTH C , FARRANT J , et al . Validation of the decontamination of a specialist transport system for patients with high consequence infectious diseases [J ] . Microorganisms , 2021 , 9 ( 12 ): 2575 .
DESHPANDE A , MANA T S C , CADNUM J L , et al . Evaluation of a sporicidal peracetic acid/hydrogen peroxide-based daily disinfectant cleaner [J ] . Infect Control Hosp Epidemiol , 2014 , 35 ( 11 ): 1414 - 1416 .
BOYCE J M , SULLIVAN L , BOOKER A , et al . Quaternary ammonium disinfectant issues encountered in an environmental services department [J ] . Infect Control Hosp Epidemiol , 2016 , 37 ( 3 ): 340 - 342 .
CADNUM J L , JENCSON A L , O’DONNELL M C , et al . An increase in healthcare-associated clostridium difficile infection associated with use of a defective peracetic acid-based surface disinfectant [J ] . Infect Control Hosp Epidemiol , 2017 , 38 ( 3 ): 300 - 305 .
WIEMKEN T L , CURRAN D R , PACHOLSKI E B , et al . The value of ready-to-use disinfectant wipes: Compliance, employee time, and costs [J ] . Am J Infect Contr , 2014 , 42 ( 3 ): 329 - 330 .
BROWN L , MARSHALL A , CONWAY L , et al . Assessing the stability and sporicidal efficacy of oxidizing disinfectants [J ] . J Hosp Infect , 2024 , 149 : 22 - 25 .
LOPUZZO M , MONTAGNA M T , TRIGGIANO F , et al . Effectiveness of hydrogen peroxide wipes for surface disinfection in healthcare facilities [J ] . Ann Ig , 2024 , 36 ( 4 ): 487 - 497 .
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