Bactericidal effects of four types of Didecyl dimethyl ammonium chloride and Benzalkonium Chloride

Defeng Li; Liang Tian; Xieshang Pan; Zhongyi Xie; Lanfen Wei

doi:10.11910/j.issn.2791-2043.2024.3.06

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Bactericidal effects of four types of Didecyl dimethyl ammonium chloride and Benzalkonium Chloride

MONOGRAPHIC STUDY | Updated：2024-11-29

- Bactericidal effects of four types of Didecyl dimethyl ammonium chloride and Benzalkonium Chloride
- Sterile Supply Vol. 3, Issue 3, (2024)
- Affiliations：
  
  1.BASTEUR (Shanghai) Disinfection Products Co., Ltd., Shanghai, 200120, China
  2.Shanghai Provincial Center for Disease Control and Prevention, Shanghai, 200120, China
  3.Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, 310051, China
- Author bio：
  
  Lanfen Wei at zjcdc0520@163.com
- Funds：
- DOI：10.11910/j.issn.2791-2043.2024.3.06
  CLC：
- Published：15 October 2024，
- Accepted：
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Li Defeng,Tian Liang,Pan Xieshang,et al.Bactericidal effects of four types of Didecyl dimethyl ammonium chloride and Benzalkonium Chloride[J].Sterile Supply,2024,03(03):147-151.
DOI：

Li Defeng,Tian Liang,Pan Xieshang,et al.Bactericidal effects of four types of Didecyl dimethyl ammonium chloride and Benzalkonium Chloride[J].Sterile Supply,2024,03(03):147-151. DOI： 10.11910/j.issn.2791-2043.2024.3.06.

摘要

Abstract

Objective

The present study intends to observe the bactericidal effects of four types of Didecyl dimethyl ammonium chloride (DDAC) and Benzalkonium Chloride (BAC).

Methods

The bactericidal effects were evaluated using a quantitative suspension test and taking

Escherichia coli

(E. coli) (8099) and

Candida albicans

(C. albicans) (ATCC 10231) as the microbial indicators.

Results

With contact time of 5 minutes and 10 minutes and a killing rate criterion of ≥99.999% for effective bactericidal effects against E. coli

the minimum effective concentrations of the four types of DDAC and BAC were 3 500 mg/L

3 500 mg/L

250 mg/L

125 mg/L

and 350 mg/L

as well as 1 750 mg/L

1 750 mg/L

175 mg/L

125 mg/L

and 250 mg/L

respectively. With a contact time of 5 minutes and 10 minutes and a killing rate criterion of ≥99.99% for effective bactericidal effects against C. albicans

the minimum effective concentrations were >28 000 mg/L

>28 000 mg/L

500 mg/L

125 mg/L

and 350 mg/L

as well as >28 000 mg/L

>28 000 mg/L

250 mg/L

125 mg/L

and 350 mg/L

respectively.

Conclusion

Compared with BAC

a quaternary ammonium compound (QAC)

the bactericidal effects of different DDACs varied substantially

which should be highly emphasized in practice so that QAC disinfectants are applied effectively.

关键词

Keywords

Dialkyl quaternary ammonium compoundsBenzalkonium ChloridesBactericidal effectsEscherichia coliCandida albicans

references

Ministry of Health of the People’s Republic of China. Technical Standard For Disinfection [S]. Beijing: Department of Health Law and Supervision, Ministry of Health, 2002.

Liu SD, Dou QY, Yi L, et al. Effect of different disinfection methods on the disinfection of medical ultrasound probes [J]. Chinese Journal of Infection Control, 2019,18(09):854-858.

K. Tan, L. Tan, Y. Han, et al, “Disinfection effect of disinfectant wipes on environmental object surface in neonatal ward,” Chinese Journal of Infection Control, vol. 17, pp. 480-484, 2018.

J.Y. He, X.J. Yu and X.P. Liu, “Effect of medical hygiene wipes on disinfecting object surface and compliance to use in an intensive care unit,” Chinese Journal of Infection Control, vol. 15, pp. 337-340, 2016.

T.G. Luo, Y.N. Liu, C.Y. Wang, et al, “Application of acidic electrolyzed oxidizing water in the control of health-care-associated infection in mobile field hospital,” Chinese Journal of Infection Control, vol. 17, pp. 819-822, 830, 2018.

State Administration for Market Regulation, Standardization Administration of the People’s Republic of China. Test method for bactericidal effect of disinfectant in laboratory: GB/T 38502—2020[S]. Beijing: Standards Press of China, 2020.

She YM, Wu XS, Wang L, et al. Disinfection effect of an compound quaternary ammonium salt disinfectant at low temperature [J]. Chinese Journal of Disinfection, 2021,38(10):721-723.

H.A. Zhao, Q.Q. Zha and S.S. Nie, “Study on the low-temperature disinfection effect of a compound quaternary ammonium salt disinfectant,” China Cleaning Industry, (no. 10,)pp. 55-59, 2023.

Liu H, Zhang MM, Cui YF, et al. Optimization of Foaming Performance of Compound Quaternary Ammonium Salt Foam Disinfectant and Evaluation of Its Killing Effect on Viruses [J]. China Animal Husbandry and Veterinary Medicine, 2022,49(12):4866-4877.

B. H. Ogilvie, A. Solis-Leal, J. B. Lopezet al., “Alcohol-free hand sanitizer and other quaternary ammonium disinfectants quickly and effectively inactivate SARS-CoV-2,” The Journal of Hospital Infection, vol. 108, pp. 142-145, 2021.

State Administration for Market Regulation, Standardization Administration of the People’s Republic of China. General requirements for ordinary objects surface disinfectant: GB 27952—2020[S]. Beijing: Standards Press of China, 2020.

State Administration for Market Regulation, Standardization Administration of the People’s Republic of China. General requirements on disinfectant for infectious focus: GB 27953—2020[S]. Beijing: Standards Press of China, 2020.

State Administration for Market Regulation, Standardization Administration of the People’s Republic of China. General requirements for skin disinfectant: GB 27951—2021[S]. Beijing: Standards Press of China, 2021.

State Administration for Market Regulation, Standardization Administration of the People’s Republic of China. General requirements for disinfectant of mucous membrane: GB 27954—2020[S]. Beijing: Standards Press of China, 2020.

Guo J. Genotyping and disinfectant resistance of carbapenem-resistant Acinetobacter baumannii in hospital infections [D]. Wuhan: Wuhan University, 2019,(05):21-23.

State Administration for Market Regulation, Standardization Administration of the People’s Republic of China. Hygienic requirements for antibacterial and bacteriostatic lotion: GB 38456—2020[S]. Beijing: Standards Press of China, 2020.

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